38. Glucose regulates the survival of newborn hippocampal neurons in the adult brain
Wang X., Chen L., Syty M.D., Wang Z., Kim T.A., Wang F., Zhang Y., Wehrle P., Nasu Y., Xiong Q.*, Ge S.*
Neuron, in press (2026)
37. From research in Japan to an independence career abroad
Nasu Y.*
Experimental Medicine, 44, 569−571 (2026)
(Original in Japanese: 那須雄介 “日本で研究→海外独立という道”, 実験医学（羊土社）44, 569−571
(2026))
36. Biosensors illuminate metabolism in vivo
Nasu Y.*
The Biochemist, 48, 22−26 (2026)
35. Potassium Ion Fluorescent Sensing from Chemically Stimulated Mammalian Cells Using
a GINKO2-Encapsulated Sensor Fibremat
Sako A., Nasu Y., Obata A., Mizuno T.*
Chemical Communications, 62, 5651−5654 (2026)
34. A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate
dynamics
Kamijo Y., Mächler P.#, Ness N.#, Vu C.Q.#, Kusakizako T.#, Mannuthodikayil J., Ku Z., Boisvert M.,
Grebenik E., Miyazaki I., Hashizume R., Sato H., Liu R., Hori Y., Tomita T., Katayama T., Furube A.,
Caraveo G., Paquet M-E., Drobizhev M., Nureki O., Arai S., Brancaccio M., Campbell R.E., Kleinfeld
D., Nasu Y.*
Nature Communications, 16, 9531 (2025)
Red lactate biosensor opens the door for simultaneous monitoring of neuronal metabolism and activity
Nasu Y.*
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics
Kamijo Y., Mächler P.#, Ness N.#, Vu C.Q.#, Kusakizako T.#, Ku Z., Boisvert M., Grebenik E., Miyazaki I., Hashizume R., Sato H., Liu R., Hori Y., Tomita T., Katayama T., Furube A., Caraveo G., Paquet M-E., Drobizhev M., Nureki O., Arai S., Brancaccio M., Campbell R.E., Kleinfeld D., Nasu Y.*
Research Square (2024) [preprint]
A red fluorescent genetically encoded biosensor for extracellular L-lactate
Nasu Y.*, Kamijo Y., Hashizume R., Sato H., Hori Y., Tomita T., Drobizhev M., Campbell R. E.*
33. Bipartite Genetically Encoded Biosensors to Sense Calcium Ion Dynamics at Membrane-
Membrane Contact Sites
Yamaguchi I.#, Barazzuol L.#, Dematteis G., Zhu W., Wen Y., Drobizhev M., Lim D., Campbell R.E., Calì
T.* and Nasu Y.*
Analytical Chemistry, 97, 19848−19861 (2025)
32. A sensitive orange fluorescent calcium ion indicator for imaging neural activity
Aggarwal A., Baker H.A., Dürst C.D., Chen I-W., Chambrier P., Gonzales J.M., Marvin J.S., Vandal M.,
Lundberg T., Sakoi K., Patel R., Wang C-Y., Visser F., Fouad Y., Sunil S., Wiens M., Terai T.,
Takahashi-Yamashiro K., Thompson R.J., Brown T.A., Nasu Y., Nguyen M.D., Gordon G.R.J.,
McFarlane S., Podgorski K., Holtmaat A., Campbell R.E., Lohman A.W.*
31. A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in
male and female mice
Depaauw-Holt L.R., Duquenne M., Hamane S., Peyrard S., Rogers B., Ireland C., Nasu Y., Fulton S.,
Bosson A., Alquier T., and Murphy-Royal C.*
Nature Communications, 16, 6372 (2025)
30. Genetically encoded fluorescent biosensor for imaging of cellular metabolism
Nasu Y.*
Experimental Medicine, 43, 175−179 (2025)
(Original in Japanese: 那須雄介 “蛍光バイオセンサーの開発と細胞代謝イメージング”, 実験医学（羊土
社）43, 175−179 (2025))
29. Functional and structural profiling of circulation via genetically encoded modular fluorescent
probes
Vittani M.#, Lee A.B.#, Wang X.#, Hiraoka Y.#, Konno A., Knak P.G., Kusk P., Nagao M., Asiminas A.,
Courtin J., Putranto M.F., Nasu Y., Tsuno S., Ueda K., Osuga Y., Tsuboi T., Bienvenu T., Terunuma M.,
Hirai H., Nedergaard M., Tanaka K.*, Hirase H.*
Postdoctoral research at the University of Alberta and the University of Tokyo
28. Synthesis and application of a photocaged L-lactate for studying the biological role of L-lactate
Miyazaki I, Tsao K.K.*, Kamijo Y, Nasu Y., Terai T*. Campbell R.E*.
Communications Chemistry, 8, 104 (2025)
27. Membrane proteins that do not need membrane?
Nasu Y.*
Seibutsu Kogakushi, 102, 626 (2024)
(Original in Japanese: 那須雄介 “膜が不要な膜タンパク質!?”, 生物工学会誌（日本生物工学会）102,
626 (2024))
26. A high-performance chemigenetic potassium ion indicator
Cheng D., Ouyang Z., He X., Nasu Y., Wen Y., Terai T.*, Campbell R.E.*
Journal of the American Chemical Society, 146, 35117−35128 (2024)
25. A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice
Fernández-Moncada I.*, Fundazuri U.B., Lavanco G., Bollmohr N., Hachaguer P., Tor T.D., Mountadem
S., Serrat R., Bellocchio L., Cannich A., Nasu Y., Campbell R.E., Drago F., Bouzier-Sore A-K., Pellerin
L., Bolaños J.P., Bonvento G., Barros L.F., Oliet S.H.R., Panatier A., Marsicano G.*
Nature Communications, 15, 6842 (2024)
24. Development of an miRFP680-Based Fluorescent Calcium Ion Biosensor Using End-Optimized
Transposons
Chai F., Fujii H., Le G. N. T., Lin C., Ota K., Lin K. M., Pham L. M. T., Zou P., Drobizhev M., Nasu Y.,
Terai T., Bito H., Campbell R. E.*
ACS Sensors, 9, 3394−3402 (2024)
23. LACCO Series: Genetically Encoded l-Lactate Biosensors
Nasu Y.*
Seibutsu Butsuri, 64, 155−158 (2024)
(Original in Japanese: 那須雄介 “乳酸の新たな役割に光を当てるLACCO（ラッコ）シリーズの開発”,
生物物理（日本生物物理学会）64, 155−158 (2024))
22. High Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular
L-Lactate
Hario S.#, Le G. N. T.#, Sugimoto H., Takahashi-Yamashiro K., Nishinami S., Toda H., Li S., Marvin J.
S., Kuroda S., Drobizhev M., Terai T., Nasu Y.*, Campbell R. E.*
ACS Central Science, 10, 402−416 (2024)
21. Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
Nasu Y.*, Aggarwal A., Le G.N.T., Vo C.T., Kambe Y., Wang X., Beinlich F.R.M., Lee A.B., Ram T.R.,
Wang F., Gorzo K.A., Kamijo Y., Boisvert M., Nishinami S., Kawamura G., Ozawa T., Toda H., Gordon
G.R., Ge S., Hirase H., Nedergaard M., Paquet M.-E., Drobizhev M., Podgorski K., Campbell R. E.*
Nature Communications, 14, 6598 (2023)
Improved genetically encoded fluorescent biosensors for monitoring of intra-and extracellular L-lactate
Nasu Y.*, Aggarwal A., Le G.N.T., Kamijo Y., Boisvert M., Paquet M.-E., Drobizhev M., Podgorski
K., Campbell R. E.*
20. Current status of fluorescent lactate biosensor development
Nasu Y.*
Bunseki Kagaku, 72, 1−4 (2023)
(Original in Japanese: 那須雄介 “蛍光乳酸センサー開発の現状”, 分析化学（日本分析化学会）72, 1−4
(2023))
19. Construction of the lactate-sensing fibremats by confining sensor fluorescent protein of lactate
inside nanofibers of the poly(HPMA/DAMA)/ADH-nylon6 core-shell fibremat
Kato Y., Iwata S., Nasu Y., Obata A., Nagata K., Campbell R.E., Mizuno T.*
RSC Advances, 13, 29584−29593 (2023)
18. Maximizing the performance of fluorescent protein-based biosensors
Chai F., Cheng D., Nasu Y.*, Terai T.*, and Campbell R. E.*
Biochemical Society Transactions, 51, 1585−1595 (2023)
17. Development of L-lactate biosensors
Nasu Y.*
(Original in Japanese: 那須雄介 “乳酸バイオセンサーの開発”, 月刊細胞（ニューサイエンス社）55,
16−19 (2023))
16. The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to
metabolically adapt mitochondria
Bassot A., Chen J., Takahashi-Yamashiro K., Yap M. C., Christine Silvia Gibhardt, Le G. N. T., Hario S.,
Nasu Y., Moore J., Gutiérrez T., Mina L., Mast H., Moses A., Bhat R., Ballanyi K., Lemieux H., Sitia R.,
Zito E., Bogeski I., Campbell R. E., Simmen T.*
Cell Reports, 42, 111899 (2023)
15. Chemigenetic indicators based on synthetic chelators and green fluorescence protein
Zhu W., Takeuchi S., Imai S., Terada T., Ueda T., Nasu Y., Terai T.*, Campbell R. E.*
Nature Chemical Biology, 19, 38−44 (2022)
14. Observation of information transmitters as they are
Nasu Y.*
(Original in Japanese: 那須雄介 ”情報伝達物質をありのままに観察”, 化学（化学同人） 77, 61−62
(2022))
13. Principles Section, Chapter 5, Advanced Analysis Techniques, Section 5, Super-Resolution
Fluorescence Microscopy, Item 1, PALM
Nasu Y.*
Cutting-edge Analytical Techniques 2nd Edition, 455−462 (2022)
(Original in Japanese: 那須雄介 “原理編 5章 先端分析法 5節 超解像蛍光顕微鏡 1項 PALM”, 先端の分析
法新訂第2版（エヌ・ティー・エス）pp. 455−462 (2022))
12. A genetically-encoded far-red fluorescent calcium ion biosensor derived from a biliverdin-
binding protein
Hashizume R., Fujii H.#, Mehta S.#, Ota K.#, Qian Y., Zhu W., Drobizhev M., Nasu Y.*, Zhang J., Bito
H.,Campbell R. E.*
Protein Science, 31, e4440 (2022)
11. Neurophotonic tools for microscopic measurements and manipulation: status report
Abdelfattah A.S., Ahuja S., Akkin T., Allu S.R., Brake J., Boas D.A., Buckley E.M., Campbell R.E., Chen
A.I.,Cheng X., Čižmár T., Costantini I., Vittorio M.D., Devor A., Doran P.R., ElKhatib M., Emiliani V.,
Fomin-Thunemann N., Fainman Y., Fernandez-Alfonso T., Ferri C.G.L., Gilad A., Han X., Harris A.,
Hillman E.M.C.,Hochgeschwender U., Holt M.G., Ji N., Kılıç K., Lake E.M.R., Li L., Li T., Mächler P.,
Miller E.W., Mesquita R.C., Nadella K.M.N.S., Nägerl U.V., Nasu Y., Nimmerjahn A., Ondráˇcková P.,
Pavone F.S., Campos C.P.,Peterka D.S., Pisano F., Pisanello F., Puppo F., Sabatini B.L., Sadegh S.,
Sakadzic S., Shoham S., Shroff S.N., Silver R.A., Sims R.R., Smith S.L., Srinivasan V.J., Thunemann
M., Tian L., Tian L., Troxler T., Valera A., Vaziri A., Vinogradov S.A., Vitale F., Wang L.V., Uhlířová H.,
Xu C., Yang C., Yang M.-H., Yellen G., Yizhar O., and Zhao Y.
Neurophotonics, 9, 013001 (2022)
10. A genetically encoded fluorescent biosensor for extracellular L-lactate
Nasu Y., Murphy-Royal C., Wen Y., Haidey J., Molina R. S., Aggarwal A., Zhang S., Kamijo Y., Paquet
M., Podgorski K., Drobizhev M., Bains J. S., Lemieux M. J., Gordon G. R., Campbell R. E.*
Nature Communications, 12, 7058 (2021)
Lactate is actually important -development of lactate biosensors-
Nasu Y.*, Campbell R.E.
The Rigakubu News, March, p. 9 (2022)
(Original in Japanese: 那須雄介 “乳酸は実は重要物質 -乳酸センサーの開発”, 理学部ニュース3月号,
p.9 (2022))
9. Structure- and mechanism-guided design of single fluorescent protein-based biosensors
Nasu Y.#, Shen Y.#, Kramer L., Campbell R. E.*
Nature Chemical Biology, 17, 509−518 (2021)
8. Engineering genetically encoded fluorescent indicators for imaging of neuronal activity: Progress and prospects
Shen Y., Nasu Y., Shkolnikov I., Kim A., Campbell R.E.*
Neuroscience Research, 152, 3−14 (2020)
7. Unnaturally aglow with a bright inner light
Nasu Y., R.E. Campbell*
Graduate research at the University of Tokyo
6. In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy
Nasu Y., Benke A., Arakawa S., Yoshida G. J., Kawamura G., Manley S., Shimizu S., Ozawa T.*
Scientific Reports, 6, 27505 (2016)
5. Genetically Encoded Fluorescent Probe for Imaging Apoptosis in Vivo with Spontaneous GFP Complementation
Nasu Y., Asaoka Y., Namae M., Nishina H., Yoshimura H., Ozawa T.*
Analytical Chemistry, 88, 838−844 (2016)
4. Development of red-shifted mutants derived from luciferase of Brazilian click beetle Pyrearinus termitilluminans
Nishiguchi T., Yamada T., Nasu Y., Ito M., Yoshimura H., Ozawa T.*
Journal of Biomedical Optics, 20, 101205 (2015)
3. A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells
Kodaka M., Yang Z., Nakagawa K., Maruyama J., Xu X., Sarkar A., Ichimura A., Nasu Y., Ozawa T., Iwasa H., Ishigami-Yuasa M., Ito S., Kagechika H., Hata Y.*
Experimental Cell Research, 336, 171−181 (2015)
2. Bioluminescent Probes to Analyze Ligand-induced Phosphatidylinositol 3,4,5-trisphosphate Production with Split Luciferase Complementation
Yang L., Nasu Y., Hattori M., Yoshimura H., Kanno A., Ozawa T.*
Analytical Chemistry, 85, 11352−11359 (2013)
1. Development of a novel method to investigate cell death (apoptosis) in living animals
Nasu Y., Takeuchi M., Ozawa T.*
Outlook and Topics, March, p.10 (2011)
(Original in Japanese: 那須雄介, 竹内雅宜, 小澤岳昌 “細胞の自殺（アポトーシス）を生きた生物の中で研究する手法を初めて開発”, 展望とトピックス（日本分析化学会）p.10 (2011))